JetBrains has done it again!
This time they have made a Python IDE, PyCharm, (currently in public preview) which looks as cool as the existing RubyMine product.
The tool allows for navigating your Python project, doing refactoring, debugging support. It supports Google App Engine and the Django web framework.
I like it!
Update: I completely forgot to include a URL to the product: http://www.jetbrains.com/pycharm/index.html